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This may include instances where: You need a stronger product to achieve your goals (e.g., deep hyperpigmentation, severe acne, etc.) You already use another product containing copper (this could be unsafe) An essential part of your skin care routine is a harsh active, vitamin C, strong exfoliant, or salicylic acid — many of which are common ingredients in acne treatments and anti-aging products (copper peptides shouldn’t be mixed with them) Using copper peptides may be unsafe (i.e., you have Wilson’s disease, a peptide allergy, or active/suspected cancer) You’ve tried a copper peptide product in the past and experienced an adverse reaction (e.g., “copper uglies” or troublesome side effects) If you’d like some alternatives to copper peptides, we go over a few in the “Alternatives to copper peptide serums” section toward the end of this guide