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As mitochondria function is determined in part by mitochondrial dynamics, the balance between fusion and fission and the expression of proteins that regulate each process can participate in the preservation of cellular integrity and determine APAP hepatotoxicity ( The specific removal of dysfunctional mitochondria through mitophagy is determined by several mechanisms, including the mitochondrial translocation of Parkin, an E3 ubiquitin ligase ( Figure 4 )
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You can walk into a mercury-free dental office expecting protection during amalgam removal and leave with more mercury exposure than you arrived with, simply because the necessary containment steps were skipped
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