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Common effects: Moderate appetite increase (less acute and intense than GHRP-6) Flushing and warmth at the injection site or face Transient drowsiness, particularly with evening doses Mild water retention and peripheral edema Increased gastrointestinal motility Less common: Moderate cortisol and ACTH elevation (comparable to hCRH per Arvat et al.) Mild prolactin elevation Numbness or tingling in extremities (GH-mediated fluid shifts) Joint stiffness at higher doses Lightheadedness post-injection Potential tachyphylaxis: Bowers and colleagues noted response attenuation after five consecutive days of GHRP-2 injections, reinforcing the rationale for periodic cycling breaks rather than continuous indefinite use

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doi: 10.1681/ASN.2010070705 109 LuXHuMC