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In a mouse model of hepatic encephalopathy, reduced expression of neuronal fractalkine, a molecule that promotes ‘off’ signaling to microglia, resulted in elevated microglia activation, with increased expression of CCL2, IL-6, and TNF-α (McMillin et al., 2016), which was also seen in a hepatic injury modeled by a bile duct ligation (Dhanda et al., 2018)

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Regulatory Status and Legal Considerations Regulatory status varies globally