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DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer
Reduced Glutathione
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unlike antibody-mediated endocytosis, cellular uptake is highly variable, depending critically on the intrinsic trafficking of the target protein or on non-specific pinocytosis, representing a major bottleneck in achieving therapeutically relevant intracellular concentrations of the PROTAC payload (Table 2) [244]
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