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The adaptive signal encourages the organism to lower effort alternative strategies, e.g., alterations of dopamine and acetylcholine influx into the prefrontal cortex that occur with prolonged task performance is adaptive in the sense that it signals the need to abandon the ongoing behavior in such a way as to promote energy conservation
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While our main focus lies on the computational aspect of the models, we provide an overview of the basic elements of biomolecular solvation (e.g., solvent structure, polarization, ion binding, and nonpolar behavior) in order to provide a background to understand the different types of solvation models
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