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The downregulation of ChaC1, along with other genes, appears to contribute to the mechanisms by which lung adenocarcinoma cells develop resistance to cisplatin, highlighting the UCA1-TXNIP axis as a potential therapeutic target for overcoming drug resistance (Zhou et al., 2020)
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In patients with multiple sclerosis, natalizumab treatment reduces the populations of integrin α-4-positive Th1, Th17 and Tregs differentially, while affecting the immune function of residual integrin α-4-positive T cells (Kimura et al
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