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It has been demonstrated that NDMA and other nitrosamines are metabolized in vitro by liver homogenates to yield the corresponding aldehyde and a chemically reactive alkylating species 39
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However, all three imaging agents proved to be stable in vivo and boasted relatively similar pharmacokinetic profiles in mice bearing GRPR-expressing PC-3 prostate cancer xenografts, suggesting that (at least in this case) the linker does not play a dramatic role in determining in vivo performance
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