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In PD, persistent microglial activation and the production of ROS lead to the release of pro-inflammatory cytokines, establishing a self-perpetuating cycle ( M1/M2 polarization of microglia plays a crucial role in neuroinflammation (Qin et al., 2019)
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Novel strategies for PI3K/AKT/mTOR pathways The activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway plays a crucial role in endocrine resistance, positioning this pathway as a potential therapeutic target
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