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In the case of LC and infectious ME/CFS, adjuvants that could induce hyperactivation and depletion of the immune system by chronic exposure would be viral antigens, interacting with genetically predisposed HLA-II alleles (HLA-DRB1), similar to ASIA syndrome ( Polymorphisms in the HLA-DRB1 gene may predispose to an altered immune response, increasing the risk of autoimmune diseases and an exaggerated response of the immune system to certain pathogens or vaccines, as in ASIA syndrome (96, 103, 104)