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Anti-inflammatory Nutrition & Weight Optimization Nutrition plays a crucial role in controlling inflammation, facilitating tissue repair, and supporting overall joint health: Emphasize lean protein, whole grains, fruits/vegetables, nuts, seeds, and omega-3-rich fish Incorporate anti-inflammatory foods: berries, leafy greens, turmeric, ginger, and olive oil Limit processed foods and refined sugars Guidance on healthy weight management, as excess body weight increases knee stress 4

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Hyperglycemia increases notch activity in vitro and vivo, and consistent activation of notch results in impaired GSIS and blocks maturation of β cells, which may be a result of degradation of MAFA due to the blockage of its binding to kat2b