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Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain
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Mouse-study observations In the Billon 2023 and Billon 2024 studies, mice dosed at 25-50 mg/kg IP for up to 28 days showed no overt toxicity, no sickness-related weight loss, no liver-enzyme signal at the doses tested, and no cardiac dysfunction
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