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An early point of TGF-β signaling regulation occurs by the cell surface molecules that exert context-dependent augmentation or inhibition of the active TGF-β ligand binding with its cognate receptors, such as auxiliary TGF-β co-receptors ( e.g ., betaglycan, endoglin, and BAMBI), small leucine-rich proteoglycans (SLRPs) that can bind and sequester TGF-β ligands ( e.g

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, 2013), as the administration of Zn alone or in combination with RibCys during stress was shown to reverse the drop in testosterone levels as seen by the non-significant difference in the levels of testosterone in the PSD+Zn and PSD+RibCys+Zn groups, when compared with the control group