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Cellular defenses are activated in response to insults to oxidized DNA and include four major repair mechanisms: 1 ) nucleotide excision repair (NER) and 2 ) base excision repair (BER), both of which excise bulky helix-distorting DNA lesions
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The important link to the levels of expression of Ih and HCN protein have recently been shown to be regulated by neuronal activity 58
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