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Levels of the deubiquitylase OTU domain-containing protein 3 (OTUD3) are decreased in PD mice overexpressing A53T α-synuclein
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Using either a mast cell stabilizer or a medication to reduce prostaglandin E2 synthesis (e.g., a COX2 inhibitor) stopped the hypersensitivity in the animal model of IBS.[ref] In the Lifehacks section (below), you’ll find a more comprehensive list of substances that also trigger mast cell degranulation
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