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Wilcoxon matched-pairs singled-ranks test was used to compare differences in oxygen consumption, energy expenditure, respiratory quotient, and physical activity, and the Bonferroni correction was applied to calculate adjusted p values

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Cagrilintide offers mechanistic synergy when combined with GLP-1 RAs.11 These complementary actions provide a strong physiological rationale for dual-hormone approaches in T2DM, particularly among individuals with obesity or weight-related complications, where energy balance is central to glycemic durability and cardiometabolic outcomes.12 Clinically, the cagrilintide–semaglutide combination (CagriSema) has advanced through randomized trials.13 In a 32-week phase 2 trial in T2DM, CagriSema produced significantly greater weight loss than semaglutide alone (−15.6% vs