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In contrast to preladenant, the A2A receptor antag- onist istradefylline was tested in several RCTs 136–138 , and a meta-analysis suggested that it can be useful to alleviate ‘off ‘ time and motor fluctuations, although the effect on dyskinesia was not clear 139
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G6PD regenerates nicotinamide adenine dinucleotide phosphate (NADPH), a coenzyme involved in anabolic reactions, thereby maintaining a reducing environment
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