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Keywords : endoplasmic reticulum stress, cancer, tumor microenvironment, unfolded protein response Endoplasmic reticulum (ER) stress represents a cellular response activated in the face of conditions such as the aggregation of misfolded and unfolded proteins within the ER lumen, as well as disruptions in calcium homeostasis[1]

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As the new obesity pharmacotherapies will lead up to 15–25% mean WL, intensive lifestyle interventions may provide small additional WL benefit to these treatments [11, 106]