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the proportion of the total amount of component (II) in the preparation, based on the total weight of the preparation, 0.0001 to 30 wt .-%, preferably 0.001 to 20 wt .-%, particularly preferably 0.001 to 5 wt .-%, is and or the proportion of the total amount of component (III) in the preparation, based on the total weight of the preparation, from 0.1 to 30 wt .-%, preferably 0.5 to 10 wt .-%, is

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The duration of urine in the bladder before urine collection might also alter the EVs in the urine sample, because bladder cells can also produce EVs, and those EVs could be altered by urine characteristics (pH, concentration, and excreted substances) (85)