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Inducing ferroptosis in HNSCC cells by RSL3 or ferroptosis inducer (FIN) 56 triggers expression of programmed cell death ligand-1, creating a more inflamed tumor microenvironment that effectively respond to anti-programmed cell death ligand-1 therapy [369]

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The reaction was incubated for 72 sec and then absorbance was measured at λ=450 nm