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As a consequence of diminished antioxidant capacity, the activity of some of the protein phosphatases, such as PTP1B, SHP-2, PTEN, and MKP, that attenuate the progression of ROS-dependent signal transduction by being subject to reversible oxidation by H 2 O 2 [15, 195] is likely to be compromised
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The most commonly changed drugs were platform therapies, first being recombinant human interferon betaβ1b, followed by recombinant human interferon betaβ1a and glatiramer acetate, and were most frequently substituted with teriflunomide and natalizumab
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