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Mooney Cells .2025
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During oxidative stress, ROS will disrupt transcription factor NRf2 binding to its negative regulator, Kelch-like enoyl-CoA hydratase-associated protein 1, in the cytoplasm leading to NRf2 translocation into the nucleus, which subsequently activates antioxidant response element and induces the transcription of several antioxidants including GSTs [60]
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