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Preclinical studies in rodent models have demonstrated that ginger administration significantly suppressed the mRNA expression of pro-inflammatory cytokines and endothelial adhesion molecules, including TNF-α, IL-1β, COX-2, MIP-1α, and MCP-1 [120]
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Embedded experimental medicine approach Incorporation of multiple readouts of a biological mechanism related to the therapeutic approach being tested within a clinical trial in order to understand the impact of the therapeutic agent on disease processes
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