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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection [PMID: 26982719] Laboratory literature summary: PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
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Although the initial results with and models of medulloblastomas and gliomas looked promising because of its efficacy in reducing tumor growth, the drug was discontinued from a Phase I trial due to renal toxicity (Diamond et al., 2010)
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