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In addition, intra-myocardial fibrosis, a hallmark of AF, was observed to increase in the atria of obese mice, as evidenced by aggravated collagen deposition, upregulated pro-fibrosis signaling (TGF-β, α-SMA, Smad3, collagen Ⅰ, and collagen Ⅲ), and downregulated transcription of anti-fibrotic Smad7 (Figures 2K–O)
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There is also observational evidence that GLP-1 RAs may protect against obesity-associated cancers (165)
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