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During the bioleaching process, the released heavy metals are toxic to the leaching microorganisms, and the stress tolerance process of the microorganisms will result in the production of reactive oxygen species (ROS) inside the cells (Stadtman and Oliver, A
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1 Introduction Colorectal cancer (CRC) is recognized as a clonal disease ( Currently, the majority of newly diagnosed CRC cases are classified as sporadic forms, lacking a family history or inherited genomic alterations, and these account for approximately 60%–65% of all CRC cases
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