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Host susceptibility factors to MAC infection, such as Mendelian susceptibility to mycobacterial disease (MSMD), alpha-1 antitrypsin (AAT) deficiency, cystic fibrosis, chronic granulomatous disease, and aging, which affect macrophage function, are indicated by the corresponding signaling cascade in macrophages ( Figure 1 )

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B12 is a vitamin that plays a crucial role in cognitive and nervous system functions