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When this organic acid increases in the blood, H⁺ increases ↓ HCO₃⁻ is used for buffering ↓ HCO₃⁻ ↓ ↓ Unmeasured anions derived from 5-oxoproline ↑ ↓ Anion Gap ↑ In other words, because 5-oxoproline increases as an "unmeasured anion," the anion gap widens