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PBC is a chronic inflammatory liver disease of multifactorial etiopathogenesis, characterized by the presence of an intrahepatic mononuclear cell infiltrate, as well as circulating autoantibodies.32,33 It has been suggested that immunological mechanisms involving T-lymphocytemediated lysis are important in the characteristic bileduct and hepatocellular damage occuring in PBC.34-36Medina et al37 evaluated the phenotype of cellular infiltrates, and the expression of lymphocyte activation, antigen recognition and cell-adhesion molecules in the livers of PBC patients
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