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Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%

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For instance, the prevalence is about 0.2% in the UK [] and ranges from 0.5% to 1% in the USA [] , 0.094% to 0.14% in Australia [] , 0.58% to 0.77% in Korea [] , and can be as high as 0.76% in Japan [] (Table 1)