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Or, during early pregnancy, if there are concerns about fetal risks associated with peak blood levels following each once-daily dose of a psychotropic drug, twice- or thrice-daily dosing may be suggested

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It should be noted that a dichotomous outcome, such as the proportion of patients who were relapse-free (the outcome used in the analysis of Munari and colleagues) instead of relapse rate (used by Martinelli Boneschi and colleagues), is a more sensitive outcome measure (70