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In cells undergoing adipogenesis, the activation of NRF2 inhibited lipid accumulation, and its influence led to a marked downregulation of the genes responsible for fatty acid synthesis in the liver [86]
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A key innovation in this field is the development of “designer probiotics”—genetically engineered or otherwise modified commensal bacterial strains specifically tailored to withstand production stresses such as lyophilization, thermal fluctuations, and gastric acidity, or to enhance their most beneficial functions for the host (537)
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