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The direct antioxidant effects of NAC is mainly through interaction of its free thiol group with free radicals, such as NO 2 and HOX ( 2+ handling proteins such as RyR2, SERCA2a and PLB, or the key modulator CaMKII ( β ) formation, which is a reaction product of nitric oxide (NO) and superoxide (O 2 β ) ( 2 ) are formed by myeloperoxidase from hydrogen peroxide (H 2 O 2 ) and nitrite (NO 2 β ) ( Differences between species in the effect of antioxidative treatment ROS has been implicated in the development of early IRA by affecting the activity of Ca 2+ handling proteins
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doi: 10.1371/journal.pone.0101937 78 YuNLiuSYiXZhangSDingY
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