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494,495 In conclusion, active research is still required in this field and a combination of treatment modalities may enhance therapeutic options for patients

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1 H NMR (400 MHz, DMSO-d 6 ) : δ ppm 8.21 (d, J = 9.2 Hz, 1H), 7.76–7.68 (m, 2H), 7.45–7.41 (m, 2H), 3.47–3.45 (m, 4H), 3.18–3.14 (m, 4H), 3.01 (s, 3H), 1.43 (s, 9H)