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Despite significant progress in understanding the underlying causes of the disease, such as the discovery of the role of testosterone, scientists are still striving to identify both environmental and genetic factors that increase susceptibility to the disease

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7a–c, Supplementary Tables 7 and 8) and led to greater relative engagement of this peptide with TMs 5, 6 and 7, relative to rAmy, which interacted more with ECL2 (Supplementary Fig