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For an excellent review of diagnostic issues in fatigue-associated conditions and brain effects, see Baraniuk (2023), FM, and GWS
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In the context of ADRD risk, cerebral hypoperfusion also appears to precede Amyloid-β (Aβ) and hyperphosphorylated tau accumulation in the ADRD pathophysiological cascade (Iturria-Medina et al., 2016), particularly in regions vulnerable to early pathology (entorhinal cortex, hippocampus, inferior parietal cortex, inferior temporal cortex) (Mattsson et al., 2014)
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