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Mitochondrial and lysosomal dysfunction, dysregulated iron metabolism, and accumulation of ROS are considered to be pivotal elements in the pathogenesis of PD, ultimately leading to neuronal degeneration and death (Matak et al., 2016
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The combination of rational protein design, directed evolution, and post-translational modifications is crucial for overcoming challenges associated with enzymatic degradation, stability, and targeted therapeutic delivery
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