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70 Although ibudilast did not significantly impact negative mood, it did reduce the odds of heavy drinking by 45% and attenuated alcohol cue-elicited activation in the ventral striatum (which is the brain region most closely associated with reward)
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doi: 10.1080/87559129.2023.2230268 282 CuiSGuJLiuXLiDMaoBZhangHet al
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