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Nature 574, 575β580
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Grade 3β4 liver injury was also observed in 25%β63% of patients with APL treated with As 2 O 3 in combination with ATTRA by Nishikawa et al., 2002) that the oral administration of DMA has a promotional effect on hepatocellular carcinoma (HCC) in rats, causing a significant increase in the level of hepatic 8-oxodG and inducing an increase in P-450 synthesis
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