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A large randomized trial in older adults found no effect of EPA and DHA on cognitive function, and the broader trial record shows little benefit in cognitively healthy people or in established Alzheimer’s, with a possible signal in early cognitive impairment and in people who do not carry APOE4
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These liver IGF-1-deficient mice were crossed with mice that express a mutant GH that acts as an antagonist, and the resulting mice showed improved insulin sensitivity and decreased blood glucose and insulin levels (175)
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