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Neuroprotection of Early and Short-Time Applying Berberine in the Acute Phase of Cerebral Ischemia: Up-Regulated pAkt, pGSK and pCREB, Down-Regulated NF-Κb Expression, Ameliorated BBB Permeability

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Compared with adults, very low exposure to glucuronide but higher exposure to sulfate, cysteine, and mercapturate metabolites was found, of which the relevance is not yet known