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The use of animal models, such as operant drug self-administration models in rodents, not only supports epidemiological findings of sex differences in drug use from humans, but also provides the advantage of parsing specific aspects of addiction, including sensitivity to drug reward, compulsive drug seeking, and relapse-like behaviors, among others (Schuster and Thompson, 1969)

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doi: 10.1038/s43018-023-00521-2 [DOI] [PubMed] [Google Scholar] 123