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On the one hand, an overabundance of ROS activates multiple transcription factors, such as NF-κB and Nrf2, thereby inducing the synthesis of proteins that govern inflammation, cellular transformation, cell viability, proliferation, invasion, angiogenesis, and metastasis

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It states only two of the following three criteria need to be met for diagnosis: Infrequent or no ovulation Raised male hormones seen as either physical signs + symptoms (such as excess hair growth, acne + hair loss) OR on blood tests Polycystic ovaries as seen on ultrasound However, The Androgen Excess Society released a report in 2009 concluding that “Based on the available data, it is the view of the AE-PCOS Society Task Force that PCOS should be defined by: The presence of hyperandrogenism (clinical and/or biochemical) Ovarian dysfunction (oligo-anovulation and/or polycystic ovaries) And the exclusion of related disorders.*” * Related disorders include hypothyroidism, raised prolactin, side effects from certain psychiatric medications and rare pituitary or adrenal diseases