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Interestingly, MDHAR can bind substrates other than MDHA, such as isoascorbic acid Evidence showed that phenoxyl radicals, like ferulic acid, quercetin, chlorogenic acid, and coniferyl alcohol, might be reduced by MDHAR [48]
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Surprisingly, another meta-analysis revealed that the expression of enzymes involved in the mitochondrial folate cycle better correlates with sensitivity to methotrexate than the cytosolic folate cycle [104]
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