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A recent phase I clinical trial (NCT03726515) revealed that the combination of EGFRvIII-CAR-T-cell therapy with anti-PD-1 therapy, pembrolizumab, did not provide clinical benefit for newly diagnosed and EGFRvIII + GBM patients (mOS, 11.8 months
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For the identification of druggable targets, we considered three classes of enzymes: “tier-1 targets”, “tier-2 targets”, and “other enzymes.” Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability
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