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S-palmitoylation hits are found in all major compartments of the endomembrane system – endoplasmic reticulum, Golgi apparatus, lysosome, endosome – as well as in mitochondria (Figure 5E)
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Managing vitamin B12 deficiency in cases of pernicious anemia requires lifelong B12 supplementation, as the autoimmune destruction of gastric parietal cells results in an irreversible lack of intrinsic factors
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