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And, because the symptoms of STXBP1 overlap with a lot of other neurodevelopmental disorders (seizures, developmental delay, intellectual disability, motor issues, etc.), we can't use symptoms to accurately identify STXBP1 patients

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However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)