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Moreover, N-acetylcysteine, angiotensin-converting enzyme inhibitors, catalase, mannitol, superoxide dismutase, and vitamin E have been shown to have antioxidant properties that help to prevent I-R injury [158]
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On one hand, studies using different animal models—hydraulic impact (vertical force transmission) versus CCI (rotational force transmission)—often produce inconsistent results, highlighting the need to examine how model-dependent differences affect clinical translation
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