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Even more locally oriented, in the patient with GABAT deficiency no abnormalities were detected in plasma or CSF, but locally decreased glutamate concentrations in the semi‐oval region of the brain were detected on brain MRS and might possibly play a pathogenic role.90 Also, mildly decreased glutamine concentrations or mildly increased glutamate concentrations may have been detected but attributed to pre‐analytical conditions rather than a reflection of in vivo metabolism as glutamine is easily spontaneously interconverted into glutamate