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All 8 binding sites can be classified into 5 types based on their coordination partners ( Table 3 ) : three “type 1” sites (Asp44, His299 from protein molecule 1, Glu236 from protein molecule 2 and a water molecule), two “type 2” sites (Asp256, Asp258 from molecule 1, His381 from molecule 2 and a water molecule), “type 3” site (His381 from molecule 1 and molecule 2, and Asp304, Asp300 form molecule 3), “type 4” (His105 from protein molecule 1 and two water molecules, one of which is H-bonded to Glu42 of the protein molecule 2) and “type 5” site (Asp256 from molecule 1, His381 residues from molecule 2, Asp339 form molecule 3, and a water molecule)

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Evidence suggests that suppression of DJ-1 enhances ferroptosis in vivo [35]